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Synthesis, Characterization and Substituent Effect on Biological Properties of Schiff Bases Derived from Anthranilic Acid
| National Conference on Innovations and Recent Trends in Engineering and Technology |
| Foundation of Computer Science USA |
| NCIRET - Number 1 |
| November 2014 |
| Authors: Avinash Joshi, Oma Ram, Naveen Kumar Mawar, Vimla Chowdhary |
| 7d2d9831-bbd2-48e8-9673-074a459f3e92 |
Avinash Joshi, Oma Ram, Naveen Kumar Mawar, Vimla Chowdhary . Synthesis, Characterization and Substituent Effect on Biological Properties of Schiff Bases Derived from Anthranilic Acid. National Conference on Innovations and Recent Trends in Engineering and Technology. NCIRET, 1 (November 2014), 14-17.
Abstract
The effect of substituents on biological activity of Schiff bases was investigated using Schiff bases derived from the condensation of oxindol with, 4-methyl anthranilic acid, 4-methoxy anthranilic acid, 4-nitro anthranilic acid, 4-chloro anthranilic acid and 4-hydroxy anthranilic acid. The synthesized compounds are characterized by elemental analysis, IR and 1HNMR. The compounds were screened against important bacteria namely Staphylococcus aureus, Escherichia coli and Bacillus Subtilis bacterial strains and for in vitro antifungal activity against Candida albicans and Aspergillus niger using the agar cup plate method and radial growth method respectively and results show that 4-chloro anthranilic acid Schiff base exhibited highest activity.
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