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Molecular Docking Studies of Dolichin A and B, Pterocarpans from Horsegram (Macrotyloma uniflorum) against HIV Replication Enzymes

by L. Rufus Auxilia, T. Mowna Sundari, Rachel Regi Daniel
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International Journal of Computer Applications
Foundation of Computer Science (FCS), NY, USA
Volume 75 - Number 14
Year of Publication: 2013
Authors: L. Rufus Auxilia, T. Mowna Sundari, Rachel Regi Daniel
10.5120/13180-0802

L. Rufus Auxilia, T. Mowna Sundari, Rachel Regi Daniel . Molecular Docking Studies of Dolichin A and B, Pterocarpans from Horsegram (Macrotyloma uniflorum) against HIV Replication Enzymes. International Journal of Computer Applications. 75, 14 ( August 2013), 19-23. DOI=10.5120/13180-0802

@article{ 10.5120/13180-0802,
author = { L. Rufus Auxilia, T. Mowna Sundari, Rachel Regi Daniel },
title = { Molecular Docking Studies of Dolichin A and B, Pterocarpans from Horsegram (Macrotyloma uniflorum) against HIV Replication Enzymes },
journal = { International Journal of Computer Applications },
issue_date = { August 2013 },
volume = { 75 },
number = { 14 },
month = { August },
year = { 2013 },
issn = { 0975-8887 },
pages = { 19-23 },
numpages = {9},
url = { https://ijcaonline.org/archives/volume75/number14/13180-0802/ },
doi = { 10.5120/13180-0802 },
publisher = {Foundation of Computer Science (FCS), NY, USA},
address = {New York, USA}
}
%0 Journal Article
%1 2024-02-06T21:44:16.597126+05:30
%A L. Rufus Auxilia
%A T. Mowna Sundari
%A Rachel Regi Daniel
%T Molecular Docking Studies of Dolichin A and B, Pterocarpans from Horsegram (Macrotyloma uniflorum) against HIV Replication Enzymes
%J International Journal of Computer Applications
%@ 0975-8887
%V 75
%N 14
%P 19-23
%D 2013
%I Foundation of Computer Science (FCS), NY, USA
Abstract

Isomeric pterocarpans, Dolichin A and Dolichin B of Macrotyloma uniflorum were docked with the three replication enzymes of HIV (Reverse transcriptase, Protease, Integrase). Analysed results proved that the docking score was high for Protease with Dolichin A (-6. 6899) and Dolichin B (-6. 6944) among Reverse transcriptase and Integrase. AIDS therapies could be scrutinized and /or replaced after the successful inihibitory effect of Dolichin. This study will support the cutting edge of HIV research and drug designing to find out a less side effect causing herbal formulations.

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Index Terms

Computer Science
Information Sciences

Keywords

Macrotyloma uniflorum Dolichin A and Dolichin B AIDS Docking

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