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Article:Comparative Study of Ligand Docking

by M.Naresh Babu, Patchikolla Satheesh, R S Datta Teja Grandhi, Prof. Allam Appa Rao
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International Journal of Computer Applications
Foundation of Computer Science (FCS), NY, USA
Volume 6 - Number 1
Year of Publication: 2010
Authors: M.Naresh Babu, Patchikolla Satheesh, R S Datta Teja Grandhi, Prof. Allam Appa Rao
10.5120/1045-1355

M.Naresh Babu, Patchikolla Satheesh, R S Datta Teja Grandhi, Prof. Allam Appa Rao . Article:Comparative Study of Ligand Docking. International Journal of Computer Applications. 6, 1 ( September 2010), 36-39. DOI=10.5120/1045-1355

@article{ 10.5120/1045-1355,
author = { M.Naresh Babu, Patchikolla Satheesh, R S Datta Teja Grandhi, Prof. Allam Appa Rao },
title = { Article:Comparative Study of Ligand Docking },
journal = { International Journal of Computer Applications },
issue_date = { September 2010 },
volume = { 6 },
number = { 1 },
month = { September },
year = { 2010 },
issn = { 0975-8887 },
pages = { 36-39 },
numpages = {9},
url = { https://ijcaonline.org/archives/volume6/number1/1045-1355/ },
doi = { 10.5120/1045-1355 },
publisher = {Foundation of Computer Science (FCS), NY, USA},
address = {New York, USA}
}
%0 Journal Article
%1 2024-02-06T19:54:17.567715+05:30
%A M.Naresh Babu
%A Patchikolla Satheesh
%A R S Datta Teja Grandhi
%A Prof. Allam Appa Rao
%T Article:Comparative Study of Ligand Docking
%J International Journal of Computer Applications
%@ 0975-8887
%V 6
%N 1
%P 36-39
%D 2010
%I Foundation of Computer Science (FCS), NY, USA
Abstract

Anti-apoptotic proteins play an vital role in deactivating the apoptosis process in cancer disease. Apoptosis process can be activated in cancer state by inhibiting anti-apoptotic proteins. Apoptosis occurs via 2 main signalling pathways the Intrinsic and Extrinsic pathways. Extrinsic pathway is regulated by p53 protein, cyt c and apaf-1 regulates the intrinsic pathway. A class of caspase cascades(2,3,6,7,8,9) helps in induction, transduction, amplification and execution of apoptotic signals in intrinsic and extrinsic signalling pathways.

References
  1. Altschul, S. F., Madden, T. L., Schaffer, A. A., Zhang, Z., Miller, W., Lipman, D. J. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25, 3389-3402
  2. Dean Y. Maeda,a, Sumit S. Mahajan,b William M. Atkinsb and John A. Zebala (April 2006) Bivalent inhibitors of glutathione S-transferase: The effect of spacer length on isozyme selectivity, J Bioorganic & Medicinal Chemistry, 3780–3783
  3. Gehlhaar, D. K.; Verkhivker, G.; Rejto, P. A.; Fogel, D. B.; Fogel, L. J.; Freer, S. T. (1995) Docking Conformationally Flexible Small Molecules Into a Protein Binding Site Through Evolutionary Programming. Proceedings of the Fourth International Conference on Evolutionary Programming, No 123-124
  4. Hayes JD, Pulford DJ (1995) The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance 30(6):445-600 , Crit Rev Biochem Mol Biol. 24-23
  5. Introduction to Bioinformatics. By, Teresa K. Attwood, David Parry-Smith. Edition, 1st edition, May 2001. Format, Paperback textbook, 240pp ...
  6. Jiao L, Bondy ML, Hassan MM, Chang DZ, Abbruzzese JL, Evans DB, Smolensky MH, Li D ( 2007): Glutathione S-transferase gene polymorphisms and risk and survival of pancreatic cancer, Cancer. No: 8-9
  7. Kidd LC, Woodson K, Taylor PR, Albanes D, Virtamo J, Tangrea JA (2003) Polymorphisms in glutathione-S-transferase genes (GST-M1, GST-T1 and GST-P1) and susceptibility to prostate cancer among male smokers of the ATBC cancer prevention study Eur J Cancer Prev.,21-22
  8. Laskowski, R. A., MacArthur, M. W., Moss, D. S. and Thronton, J. M. (1993) PROCHECK: a program to check the stereochemical quality of protein structures. J. Appl. Cryst. 26, 283-291
  9. Ramachandran, G. N., Sasisekharan, V. (1968) Conformation of polypeptides and proteins. Adv. Protein Chem. 23, 283-438.
  10. Sali, A. and Blundell, T. L. (1995) Comparative protein modelling by satisfaction of spatial restraints. J. Mol. Biol. 234, 779-815.
  11. Sheehan D, Meade G, Foley VM, Dowd CA(2001) Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily. Biochem J. Nov 15;
  12. FOR BOOK REFERNCE DataMining – Concepts and Techniques – JIAWEL HAN & MICHELINE KAMBER Harcourt India.
Index Terms

Computer Science
Information Sciences

Keywords

Computer Science Computer Engineering Interdisciplinary Research Diabetes mellitus Rigid Docking anti apoptotic proteins

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