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Modeling the Interactions between the BDNF Peptides and TrkB Receptor

by Dharmaiah Devarapalli, Allam Appa Rao, G R Sridhar
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International Journal of Computer Applications
Foundation of Computer Science (FCS), NY, USA
Volume 55 - Number 9
Year of Publication: 2012
Authors: Dharmaiah Devarapalli, Allam Appa Rao, G R Sridhar
10.5120/8786-2759

Dharmaiah Devarapalli, Allam Appa Rao, G R Sridhar . Modeling the Interactions between the BDNF Peptides and TrkB Receptor. International Journal of Computer Applications. 55, 9 ( October 2012), 42-45. DOI=10.5120/8786-2759

@article{ 10.5120/8786-2759,
author = { Dharmaiah Devarapalli, Allam Appa Rao, G R Sridhar },
title = { Modeling the Interactions between the BDNF Peptides and TrkB Receptor },
journal = { International Journal of Computer Applications },
issue_date = { October 2012 },
volume = { 55 },
number = { 9 },
month = { October },
year = { 2012 },
issn = { 0975-8887 },
pages = { 42-45 },
numpages = {9},
url = { https://ijcaonline.org/archives/volume55/number9/8786-2759/ },
doi = { 10.5120/8786-2759 },
publisher = {Foundation of Computer Science (FCS), NY, USA},
address = {New York, USA}
}
%0 Journal Article
%1 2024-02-06T20:56:50.429770+05:30
%A Dharmaiah Devarapalli
%A Allam Appa Rao
%A G R Sridhar
%T Modeling the Interactions between the BDNF Peptides and TrkB Receptor
%J International Journal of Computer Applications
%@ 0975-8887
%V 55
%N 9
%P 42-45
%D 2012
%I Foundation of Computer Science (FCS), NY, USA
Abstract

The BDNFTrkB signaling system which plays a major role in the regulation of neuronal activity. This neuronal regulation influences the potential role of this system in the therapeutic efficacy of many neurological and psychiatric disorders. Despite these roles decreased levels of BDNF are associated with diabetes and obesity which can be regulated by increasing the insulin sensitivity and glucose tolerance. BDNF mediated signaling through phosphoinositide 3-kinase (PI3K) pathway plays a key role in insulin sensitivity. These beneficial effects of BDNF as antidiabetic agents can be enhanced by the activating BDNFTrkB signaling. These multiple functionality of BDNFTrkB complex relies on the protein-protein interactions where those interactions are important in designing pharmacological targets. This apporach focus the use of BDNF peptides in place of BDNF protein in binding to the TrkB receptor. Protein–peptide docking studies were performed to know the interactions of the TrkB and BDNF peptides. Docking studies were done using ZDOCK pro (Accerlys Discovery studio). The interacting amino acids residues identified at the binding site were THR 306, LYS 308, CYS 5 ASP 370.

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Index Terms

Computer Science
Information Sciences

Keywords

BDNFTrkB signaling system Protein–protein interactions Protein–peptide interaction Diabetes mellitus

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