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Computational Investigation on Anti Cancer Compounds against Aldose Reductase as Anti Diabetic Agents

by Naresh Babu Muppalaneni, Prof. Allam Appa Rao
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International Journal of Computer Applications
Foundation of Computer Science (FCS), NY, USA
Volume 31 - Number 2
Year of Publication: 2011
Authors: Naresh Babu Muppalaneni, Prof. Allam Appa Rao
10.5120/3795-5226

Naresh Babu Muppalaneni, Prof. Allam Appa Rao . Computational Investigation on Anti Cancer Compounds against Aldose Reductase as Anti Diabetic Agents. International Journal of Computer Applications. 31, 2 ( October 2011), 14-18. DOI=10.5120/3795-5226

@article{ 10.5120/3795-5226,
author = { Naresh Babu Muppalaneni, Prof. Allam Appa Rao },
title = { Computational Investigation on Anti Cancer Compounds against Aldose Reductase as Anti Diabetic Agents },
journal = { International Journal of Computer Applications },
issue_date = { October 2011 },
volume = { 31 },
number = { 2 },
month = { October },
year = { 2011 },
issn = { 0975-8887 },
pages = { 14-18 },
numpages = {9},
url = { https://ijcaonline.org/archives/volume31/number2/3795-5226/ },
doi = { 10.5120/3795-5226 },
publisher = {Foundation of Computer Science (FCS), NY, USA},
address = {New York, USA}
}
%0 Journal Article
%1 2024-02-06T20:17:03.973508+05:30
%A Naresh Babu Muppalaneni
%A Prof. Allam Appa Rao
%T Computational Investigation on Anti Cancer Compounds against Aldose Reductase as Anti Diabetic Agents
%J International Journal of Computer Applications
%@ 0975-8887
%V 31
%N 2
%P 14-18
%D 2011
%I Foundation of Computer Science (FCS), NY, USA
Abstract

An investigation has been carried out to find out the anti cancerous compounds can exhibit anti diabetic against aldose reductase. Diabetes and cancer are common diseases worldwide. In our study we have taken 17 anti cancerous compounds from inhouse chalcones database to perform docking studies. It reveals that there are some compounds which are binding with high affinity than the average docking score -126.048 kcal/mol of ligands of the 1AH3 protein. The anti cancer compounds exhibit high docking score than the average -126.048 kcal/mol. The anti cancer compound can be used as anti diabetic.

References
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Index Terms

Computer Science
Information Sciences

Keywords

Bioinformatics Docking studies anti cancer anti diabetic

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