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Docking Studies of Green Tea Flavonoids as Insulin Mimetics

by Jayasree Ganugapati, Sirisha Mukkavalli, A.Sahithi
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International Journal of Computer Applications
Foundation of Computer Science (FCS), NY, USA
Volume 30 - Number 4
Year of Publication: 2011
Authors: Jayasree Ganugapati, Sirisha Mukkavalli, A.Sahithi
10.5120/3627-5063

Jayasree Ganugapati, Sirisha Mukkavalli, A.Sahithi . Docking Studies of Green Tea Flavonoids as Insulin Mimetics. International Journal of Computer Applications. 30, 4 ( September 2011), 48-52. DOI=10.5120/3627-5063

@article{ 10.5120/3627-5063,
author = { Jayasree Ganugapati, Sirisha Mukkavalli, A.Sahithi },
title = { Docking Studies of Green Tea Flavonoids as Insulin Mimetics },
journal = { International Journal of Computer Applications },
issue_date = { September 2011 },
volume = { 30 },
number = { 4 },
month = { September },
year = { 2011 },
issn = { 0975-8887 },
pages = { 48-52 },
numpages = {9},
url = { https://ijcaonline.org/archives/volume30/number4/3627-5063/ },
doi = { 10.5120/3627-5063 },
publisher = {Foundation of Computer Science (FCS), NY, USA},
address = {New York, USA}
}
%0 Journal Article
%1 2024-02-06T20:16:07.975769+05:30
%A Jayasree Ganugapati
%A Sirisha Mukkavalli
%A A.Sahithi
%T Docking Studies of Green Tea Flavonoids as Insulin Mimetics
%J International Journal of Computer Applications
%@ 0975-8887
%V 30
%N 4
%P 48-52
%D 2011
%I Foundation of Computer Science (FCS), NY, USA
Abstract

Diabetes Mellitus is a metabolism disorder where glucose, principal source of energy cannot enter the cells due to deficiency of insulin. In the present study, insilico approach was used to asses the use of natural green tea flavonoids as potential agents that could act as insulin receptor activators and reduce the harmful effects of diabetes. Docking studies of green tea flavanoids were carried out using Auto Dock 4.0 and Argus lab 4.0.1. Analysis of the results of both the docking softwares suggested that epicatechin can act as a potent insulin receptor activator.

References
  1. Anderson, R. A.; Polansky, M. M. Tea enhances insulin activity. J. Agric. Food Chem. 2002, 50, 7182-7186.
  2. Broadhurst, C. L.; Polansky, M. M.; Anderson, R. A. Insulin like biological activity of culinary and medicinal plant aqueous extracts in vitro. J. Agric. Food Chem. 2000, 48, 849-852.
  3. Gunsteren V,et al. Gromos 96 manual and user guide. Bimolecular Simulation
  4. Guex N,Peitsch MC. Swiss Model and the Swiss Pdb-Viewer: An environment for comparative protein modeling. Electrophoresis .,18:2714-2723
  5. Kao, Y. H.; Chang, H. H.; Lee, M. J.; Chen, C. L. Tea, obesity, and diabetes. Mol. Nutr. Food Res. 2006, 50, 188-210
  6. Morris G.M, Goodsell D.S, et al.(1998) Automated Docking Using A Lamarckian Gentic and Empirical Binding Free Energy Function. J.Computational Chemistry, 19: 1639-1662
  7. Pushparaj PN, Tan CH, Tan BKH (2001). The mechanism of hypoglycemic action of the semi-purified fractions of Averrhoa bilimbi in streptozotocin diabetic rats. Life Sci., 70: 535-547.
  8. Thompson .& A.Mark “ ArgusLab 4.0.1” www.arguslab.com Planaria Software LLC, Seattle, WA
  9. United States Department of Agriculture (USDA) Database for Flavonoid content of selected Foods www.nal.usda.gov/fnic/foodcomp
  10. Wolfram, S.; Wang, Y.; Thielecke, F. Anti-obesity effects of green tea: From bedside to bench. Mol. Nutr. Food Res. 2006,50, 176.
Index Terms

Computer Science
Information Sciences

Keywords

Green tea flavonoids Diabetes mellitus Interdisciplinary Research Applications of Computer Science Techniques for medical diagnosis Docking AUTO DOCK

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