We apologize for a recent technical issue with our email system, which temporarily affected account activations. Accounts have now been activated. Authors may proceed with paper submissions. PhDFocusTM
CFP last date
20 November 2024
Reseach Article

Computational Approaches in Tissue Engineering

by M. K. Sah, J. Sadanand, K. Pramanik
International Journal of Computer Applications
Foundation of Computer Science (FCS), NY, USA
Volume 27 - Number 4
Year of Publication: 2011
Authors: M. K. Sah, J. Sadanand, K. Pramanik
10.5120/3290-4484

M. K. Sah, J. Sadanand, K. Pramanik . Computational Approaches in Tissue Engineering. International Journal of Computer Applications. 27, 4 ( August 2011), 13-20. DOI=10.5120/3290-4484

@article{ 10.5120/3290-4484,
author = { M. K. Sah, J. Sadanand, K. Pramanik },
title = { Computational Approaches in Tissue Engineering },
journal = { International Journal of Computer Applications },
issue_date = { August 2011 },
volume = { 27 },
number = { 4 },
month = { August },
year = { 2011 },
issn = { 0975-8887 },
pages = { 13-20 },
numpages = {9},
url = { https://ijcaonline.org/archives/volume27/number4/3290-4484/ },
doi = { 10.5120/3290-4484 },
publisher = {Foundation of Computer Science (FCS), NY, USA},
address = {New York, USA}
}
%0 Journal Article
%1 2024-02-06T20:12:55.006723+05:30
%A M. K. Sah
%A J. Sadanand
%A K. Pramanik
%T Computational Approaches in Tissue Engineering
%J International Journal of Computer Applications
%@ 0975-8887
%V 27
%N 4
%P 13-20
%D 2011
%I Foundation of Computer Science (FCS), NY, USA
Abstract

Scaffolds designed with intricate and controlled interior architecture represent a challenging problem for tissue engineering. Various scaffold-fabricating techniques allow the creation of complex micro-structure but with irregular pore characteristics, resulting in inappropriate & asymmetrical structures not suitable for tissue engineering applications. Computer-Aided Tissue Engineering (CATE) integrates advanced technologies from Biology, Information Science and Engineering for Tissue Engineering applications. In particulars, computer-aided design (CAD), medical image processing, computer-aided manufacturing (CAM), and solid freeform fabrication (SFF) are employed for simulation, design and manufacturing of tissue scaffolds with controlled and regular pore architecture. CATE application to the design and fabrication of scaffolds can guide to improve the biomimetic and biological features of the scaffolds. This paper aims to understand the principles behind various computer aided approaches being utilized for tissue engineering applications particularly cell-scaffold implant modeling, designing and manufacturing.

References
  1. Langer, R. and Vacant, J.P. 1993. Tissue engineering. Scienc. 260, 920–926.
  2. Drumheller, P. and Hubbel, J. 2000. The biomedical engineering handbook. CRC Press LLC, Boca Raton, Florida.
  3. Akhyari, P., Kamiya, H., Haverich, A., Karck, M. and Lichtenberg, A. 2008. Myocardial tissue engineering: the extracellular matrix. Eur J Cardiothorac Surg. 34, 229-241.
  4. Melchels, F. 2009. Preparation of advanced porous structures by stereolithography for application in tissue engineering. Doctoral Thesis. University of Twente.
  5. Sachlos, E. and Czernuszk, J.T. 2003. Making tissue engineering scaffolds work. Review on the application of solid freeform fabrication technology to the production of tissue engineering scaffolds. Eur J cells and materials. 5, 29- 40.
  6. Tan, K. H., Chua, C. K., Leong, K. F., Naing, M.W. and Cheah, C. M. 2005. Fabrication and characterization of three-dimensional poly(ether–ether–ketone)–hydroxyapatite biocomposite scaffolds using laser sintering. In Proceedings of the IMechE, J. Engineering in Medicine. 219,183-194.
  7. Sun, W., Darling, A., Starly, B. and Nam, J. 2004. Computer-aided tissue engineering: overview, scope and challenges. J. Biotechnol Appl Biochem. 391, 29–47.
  8. Sun, W. and Lal, P. 2002. Recent development on computer aided tissue engineering review. J. Comput Methods Programs Biomed. 67, 85–103.
  9. Darling, A. and Sun, W. 2004. 3D Microtomographic characterization of precision extruded poly-3 caprolactone tissue scaffolds. J. BiomedMater Res. 70, 311–7.
  10. Hollister, S., Levy, R., Chu, T., Hollaran, J. and Feinberg, S. 2000. An image based approach for designing and manufacturing of craniofacial scaffolds. J. Oral Maxillofacial Surg. 29, 67–71.
  11. Wang, F., Shor, L., Darling, A., Khalil, S. and Sun, W. 2004. Precision extruding deposition and characterization of cellular poly-3-caprolactone tissue scaffolds. J. Rapid Prototyping.10, 42–9.
  12. Matsumura, T., Sato-Matsumura, K. C., Yokota, T., Kobayashi, H., Nagashima, K. and Ohkawara, A. 1994. Three-dimensional reconstruction in dermatopathology-a personal computer-based system. J. Cutan Pathol, 26,197–200.
  13. Taguchi, M. and Kohsuke, C. 2003. Computer reconstruction of the threedimensional structure of mouse cerebral ventricles. J. Brain Res Protoc. 12, 10–15.
  14. Sun, W., Darling, A., Starly, B. and Nam, J. 2005. Bio-CAD modeling and its applications in computer-aided tissue engineering. J. Computer-Aided Design. 37, 1097–1114.
  15. Greschus, S., Kiessling, F., Lichy, M. P., Moll. J., Mueller, M. M., Savai, R., Rose, F., Ruppert, C., Gunther, A., Luecke, M., Fusenig, N. E., Semmler, W. and Traupe, H. 2005. Potential applications of flat-panel volumetric CT in morphologic and functional small animal imaging. J. Neoplasia. 7, 730–740.
  16. Guerrero, T., Castillo, R., Sanders, K., Price, R., Komaki, R. and Cody, D. 2006. Novel method to calculate pulmonary compliance images in rodents from computed tomography acquired at constant pressures.J. Phys Med Biol. 51, 1101–1112.
  17. Kiessling, F., Greschus, S., Lichy, M. P., Bock, M., Fink, C., Vosseler, S., Moll, J., Mueller, M.M., Fusenig, N. E., Traupe, H. and Semmler, W. 2004. Volumetric computed tomography (VCT): a new technology for noninvasive, high resolution monitoring of tumor angiogenesis. J. Nat Med. 10, 1133–1138.
  18. Haczku, A., Emami, K., Fischer, M. C., Kadlecek, S., Ishii, M., Panettieri, R. A. and Rizi, R. R. 2005. Hyperpolarized He-3 MRI in asthma: measurements of regional ventilation following allergic sensitization and challenge in micepreliminary results. J. Acad Radiol. 12, 1362–1370.
  19. Wilfred, W., Lam, W., David, H., Louise, Y., Du, M. D., David, G., Cormack, Mc. and Giles, E., Santyr. 2007. Micro-CT imaging of rat lung ventilation using continuous image acquisition during xenon gas contrast enhancement. J. Appl Physiol. 103, 1848–1856.
  20. Dewey, M., Teige, F. and Schnapauff, D. 2006. Noninvasive Detection of Coronary Artery Stenoses with Multislice Computed Tomography or Magnetic Resonance Imaging. J. Annals of Internal Medicine. 145, 407-415.
  21. Detre, J.A., Samuels, O.B., Alsop, D.C., Gonzalez-At, J.B., Kasner,S. E. and Rapes, C.E. 1999. Noninvasive Magnetic Resonance Imaging Evaluation of Cerebral Blood Flow with Acetazolamide Challenge in Patients with Cerebrovascular Stenosi. J. Magnetic Resonance Imaging. 10, 870–875.
  22. Khalil, S., Nam, J. and Sun, W. 2005. Multi-nozzle deposition for construction of 3D biopolymer tissue scaffolds. J. Rapid Prototyping. 11, 9–17.
  23. Wendel, B., Rietzel, D., Kuhnlein, F., Feulner, R., Hulder, G. and Schmachtenberg, E. 2008. Additive Processing of Polymer. J. Macromolecular Materials and Engineering. 2937-99.
  24. Hutmacher, D.W., Sittinger, M. and Risbud, M.V. 2004. Scaffold-based tissue engineering: rationale for computer-aided design and solid freeform fabrication systems. J. Trends in Biotechnology. 22, 354-362.
  25. Wohlers, T. 2004. Rapid prototyping & tooling state of the industry. Fort Collins Ltd.
  26. Yang, A., Leong, K. F., Du, Z., Chua, C. K. 2002. The design of scaffolds for use in tissue engineering. Part II. Rapid prototyping techniques. J. Tissue Eng. 8, 1–11.
  27. Boland, T., Xu, T., Damon, B. and Cui, X. 2006. Application of inkjet printing to tissue engineering. J. Biotechnol. 1, 910-7.
  28. Ilkhanizadeh, S., Teixeira, A. I. and Hermanson, O. 2007. Inkjet printing of macromolecules on hydrogels to steer neural stem cell differentiation. J. Biomaterials. 28, 3936-3943.
  29. Percin, G. and Khuri-Yakub, B.T. 2002. Piezoelectrically actuated flextensional micromachined ultrasound transducers. J. Ultrasonics. 40, 441–448.
  30. Elrod, S. A., Hadimioglu, B., Khuri-Yakub, B. T., Rawson, E. G., Richley, E., Quate, C. F., Mansour, N. N. and Lundgren, T. S. 1989. Nozzleless droplet formation with focused acoustic beams. J. Appled Physics. 65, 3441.
  31. Demirci, U. and Montesano, G. 2007. Single cell epitaxy by acoustic picolitre droplets. J. Lab Chip. 7, 1139–1145.
Index Terms

Computer Science
Information Sciences

Keywords

computer-aided tissue engineering scaffold manufacturing CAD CAM SFF 3D printing