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A Bioparticle Separator based on Dielectrophoretic Integrated with Acoustic Force: Design and Simulation
| International Journal of Computer Applications |
| Foundation of Computer Science (FCS), NY, USA |
| Volume 184 - Number 3 |
| Year of Publication: 2018 |
| Authors: Alireza Dehghani, Alireza Kashaniniya |
10.5120/ijca2018916095
|
Alireza Dehghani, Alireza Kashaniniya . A Bioparticle Separator based on Dielectrophoretic Integrated with Acoustic Force: Design and Simulation. International Journal of Computer Applications. 184, 3 ( Jan 2018), 6-11. DOI=10.5120/ijca2018916095
Abstract
In this paper, we introduce the application of a microfluidic separator for detection and focusing of two different bio-particles with an integrated method utilizing acoustic and dielectrophoretic (DEP) force. In order to improve separation efficiency, we have integrated two different manipulation techniques. The separator designed and simulated relay on the combination of long-range acoustic waves and short-rang dielectrophoretic forces. The DEP manipulation is generated by an DC or AC non-uniform electronic field, while, acoustic force created using IDTs (Inter Digitated Transducers) patterned on a piezoelectric substrate such as Linbo3 (Lithium Niobate) to generate standing surface acoustic waves. The generated waves move through the PDMS (Polydimethylsiloxane) microchannel located between two same IDTS. We have two different separation steps. In the first step, particles will face with acoustic force to be focused in midline of the microchannel. In the second step, focused particles, will separated with a non-uniform electric field generated by metric 3D electrodes of Al (Aluminum) mold to the channel wall. These particles will separate and move to the different outlets. First kind of particles have a different manner of the second ones based on differ of their electrical properties. We counted the number of particles in the two different outlets at the end of separating process. Particles numbers showed a well separation efficiency. The method mentioned above is a process that that is enough flexible to utilize in a variety of applications especially in biological purposes.
References
- P. Bannasch, Cancer Diagnosis: Early Detection, Springer, Berlin, New York, 1992.
- J.M. Elwood and S. B. Sutcliffe, Cancer Control, Oxford University Press, Oxford, New York, 2010.
- W. E. O’Donnell, in Early Detection and Diagnosis of Cancer, ed. W.E. O’Donnell, E. Day and L. Venet, C.V. Mosby Co., Saint Louis,1962.
- M. Verma, B. K. Dunn, A. Umar, New York Academy of Sciences and National Cancer Institute (U.S.), Division of Cancer Prevention, Epigenetics in Cancer Prevention: Early Detection and Risk Assessment, New York Academy of Sciences, New York, 2003.
- Peter R. C. Gascoyn and Jody V. Vykoukal, Proc IEEE Inst Electr Electron Eng, Dielectrophoresis-Based Sample Handling in General-Purpose Programmable Diagnostic Instruments, 2004 January 1; 92(1): 22–42.
- J. Voldman, Annual Review of Biomedical Engineering, ELECTRICAL FORCES FOR MICROSCALE CELL MANIPULATION, 2006, 8, 425-454.
- C.H.Kua, Y.C. Lam,C.Yang and K.Youcef-Toumi, Review of bio-particle manipulation using dielectrophoresis, Singapore-MIT Alliance, 2005.
- Nyborg WL. Physical Mechanisms for Biological Effects of Ultrasound.Washington, DC: Department of Health, Education, and Welfare; 1978.
- L. A. Crum, Acoustic force on a liquid droplet in an acousticstationary wave, J. Acoust. Soc. Am., 1971, 50, 157–163.
- H. M. Hertz, Standing-wave acoustic trap for nonintrusivepositioning of microparticles, J. Appl. Phys., 1995, 78, 4845–4849.
- J. J. Hawkes, D. Barrow and W. T. Coakley, Microparticle manipulation in millimetre scale ultrasonic standing wave chambers, Ultrasonics, 1998, 36, 925–931.
- K. Yasuda, Non-destructive, non-contact handling method for biomaterials in micro-chamber by ultrasound, Sens. Actuators, B,2000, 64, 128–135.
- J. J. Hawkes and W. T. Coakley, Force field particle filter, combining ultrasound standing waves and laminar flows, Sens.Actuators, B, 2001, 75, 213–222.
- M. Wiklund, S. Nilsson and H. M. Hertz, Ultrasonic trapping in capillaries for trace-amount biomedical analysis, J. Appl. Phys.,2001, 90, 421–426.
- H. A. Pohl, Dielectrophoresis the behavior of neutral matter in nonuniform electric fields, Cambridge University Press, Cambridge, 1978.
- B. H. Lapizco-Encinas and M. Rito-Palomares, Electrophoresis, 2007, 28, 4521-4538.
- G. A. N. Ulrich Zimmermann, 2006.
- C. Zhang, K. Khoshmanesh, A. Mitchell and K. Kalantar-zadeh, Anal Bioanal Chem, 2010,396, 401-420.
- Nurhaslina Abd Rahman, Fatimah Ibrahim, and Bashar Yafouz, Dielectrophoresis for Biomedical Sciences Applications: A Review, Sensors (Basel). 2017 March; 17(3): 449.
- Takashima, S., Electrical Properties of Biopolymers and Membranes, Bristol, Adam Hilger 1989.
- Irimajiri, A., Hanai, T., Inouye, A., J. Theor. Biol. 1979,78, 251–269.
- Hu, Q., Joshi, R. P., Beskok, A., J. Appl. Phys. 2009, 106,8, 024701 (1–8).
- Asami, K., Irimajiri, A.,Biochim. Biophys. Acta 1984, 778, 570–578.
- Talukder Z. Jubery, Soumya K. Srivastava, Prashanta Dutta1, Dielectrophoretic separation of bioparticles in microdevices: A review, Electrophoresis 2014, 35, 691–713.
- Y.K. K. Yosioka, Acoustic radiation pressure on a compressible sphere, Acustica, 5(1955) 167-73.
- T. Laurell, F. Petersson, A. Nilsson, Chip integrated strategies for acoustic separation and manipulation of cells and particles, Chem Soc Rev, 36(2007)492-506.
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