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Necessity of Bio-imaging Hybrid Approaches Accelerating Drug Discovery Process (Mini-Review)

by Iliyana Samardzhieva, Aamir Khan
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International Journal of Computer Applications
Foundation of Computer Science (FCS), NY, USA
Volume 182 - Number 6
Year of Publication: 2018
Authors: Iliyana Samardzhieva, Aamir Khan
10.5120/ijca2018917564

Iliyana Samardzhieva, Aamir Khan . Necessity of Bio-imaging Hybrid Approaches Accelerating Drug Discovery Process (Mini-Review). International Journal of Computer Applications. 182, 6 ( Jul 2018), 1-10. DOI=10.5120/ijca2018917564

@article{ 10.5120/ijca2018917564,
author = { Iliyana Samardzhieva, Aamir Khan },
title = { Necessity of Bio-imaging Hybrid Approaches Accelerating Drug Discovery Process (Mini-Review) },
journal = { International Journal of Computer Applications },
issue_date = { Jul 2018 },
volume = { 182 },
number = { 6 },
month = { Jul },
year = { 2018 },
issn = { 0975-8887 },
pages = { 1-10 },
numpages = {9},
url = { https://ijcaonline.org/archives/volume182/number6/29763-2018917564/ },
doi = { 10.5120/ijca2018917564 },
publisher = {Foundation of Computer Science (FCS), NY, USA},
address = {New York, USA}
}
%0 Journal Article
%1 2024-02-07T01:10:32.082222+05:30
%A Iliyana Samardzhieva
%A Aamir Khan
%T Necessity of Bio-imaging Hybrid Approaches Accelerating Drug Discovery Process (Mini-Review)
%J International Journal of Computer Applications
%@ 0975-8887
%V 182
%N 6
%P 1-10
%D 2018
%I Foundation of Computer Science (FCS), NY, USA
Abstract

Imaging technologies have made a significant improvement in the past few decades and their application made a great impact on accelerating the process of drug discovery and development. The ability to non-invasively image an animal model or co-cultured live cells and validate potential drug target, biomarkers of drug efficacy and assess a pharmacological drug interaction significantly contributes to the process of translating molecules into medicines. This paper summarizes current trends in bio-imaging technologies and their application on the process of drug discovery. In particular, High Content Screening (HCS) and Virtual Screening (VS) are reviewed, and their respective examples are discussed to gain insight into state-of-the-art bio-imaging methodologies used for extracting knowledge and its application to drug discovery. This paper argues the need to reduce the gap between experimental (e.g. HCS based assays) and theoretical (e.g. VS based assays) assays. Although HCS and VS are leading drug discovery choices for the pharmaceutical industry and such investigations have been carried out in their respective campaign, the potential effects of these approaches together to facilitate the process of drug discovery has rarely been reported. Further, the prevalent research trends on developing hybrid approaches such as VS complementing HCS implies substantial enhancement to the goal of reliable drug candidate identification.

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Index Terms

Computer Science
Information Sciences

Keywords

Bio-imaging drug discovery high-content screening virtual screening

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