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Reseach Article

Efficient, Ultra-facile Breast Cancer Histopathological Images Classification Approach Utilizing Deep Learning Optimizers

by Sarpong Kwadwo Asare, Fei You, Obed Tettey Nartey
International Journal of Computer Applications
Foundation of Computer Science (FCS), NY, USA
Volume 177 - Number 37
Year of Publication: 2020
Authors: Sarpong Kwadwo Asare, Fei You, Obed Tettey Nartey
10.5120/ijca2020919875

Sarpong Kwadwo Asare, Fei You, Obed Tettey Nartey . Efficient, Ultra-facile Breast Cancer Histopathological Images Classification Approach Utilizing Deep Learning Optimizers. International Journal of Computer Applications. 177, 37 ( Feb 2020), 1-9. DOI=10.5120/ijca2020919875

@article{ 10.5120/ijca2020919875,
author = { Sarpong Kwadwo Asare, Fei You, Obed Tettey Nartey },
title = { Efficient, Ultra-facile Breast Cancer Histopathological Images Classification Approach Utilizing Deep Learning Optimizers },
journal = { International Journal of Computer Applications },
issue_date = { Feb 2020 },
volume = { 177 },
number = { 37 },
month = { Feb },
year = { 2020 },
issn = { 0975-8887 },
pages = { 1-9 },
numpages = {9},
url = { https://ijcaonline.org/archives/volume177/number37/31144-2020919875/ },
doi = { 10.5120/ijca2020919875 },
publisher = {Foundation of Computer Science (FCS), NY, USA},
address = {New York, USA}
}
%0 Journal Article
%1 2024-02-07T00:47:58.569659+05:30
%A Sarpong Kwadwo Asare
%A Fei You
%A Obed Tettey Nartey
%T Efficient, Ultra-facile Breast Cancer Histopathological Images Classification Approach Utilizing Deep Learning Optimizers
%J International Journal of Computer Applications
%@ 0975-8887
%V 177
%N 37
%P 1-9
%D 2020
%I Foundation of Computer Science (FCS), NY, USA
Abstract

Conventional approaches to breast cancer diagnosis are associated with drawbacks that ultimately affect the quality of diagnosis and subsequent treatment, pushing for the need for automatic and precise classification of breast cancer tumors. The advent of deep learning methods has witnessed an increasing interest in their applications in many tasks. The specific case of using convolutional neural networks with transfer learning has witnessed tremendous successes in many classification tasks. Nonetheless, with transfer learning, the sheer number of parameters associated with deep networks coupled with the distance disparity between source data and target data leave networks prone to overfitting, particularly in the case of limited data. Also, negative transfer may occur in the situation where the source and target domains are not related. This work proposes a simple convolutional neural network model trained from scratch for discriminating benign and malignant breast cancer tumors in histopathological images. Four deep learning optimization algorithms are leveraged and explored to ascertain how optimizers aid in finding good sets of parameters that help minimize loss and increase overall classification accuracy. By adopting a polynomial learning rate decay scheduling and implementing several data augmentation techniques that regulate overfitting and improve the generalization ability of the proposed model, accuracy, sensitivity, specificity, and Area Under the Curve values of 89.92%, 94.02%, 86.42%, and 0.884 (88.4%), respectively are reported.

References
  1. K. D. Miller et al., ?Cancer treatment and survivorship statistics, 2016,? CA. Cancer J. Clin., 2016.
  2. D. A. Ragab, M. Sharkas, S. Marshall, and J. Ren, ?Breast cancer detection using deep convolutional neural networks and support vector machines,? PeerJ, 2019.
  3. R. A. Smith, V. Cokkinides, and H. J. Eyre, ?American Cancer Society Guidelines for the Early Detection of Cancer, 2006,? CA. Cancer J. Clin., 2006.
  4. J. G. Elmore et al., ?Diagnostic concordance among pathologists interpreting breast biopsy specimens,? JAMA - J. Am. Med. Assoc., 2015.
  5. Y. Lecun, Y. Bengio, and G. Hinton, ?Deep learning,? Nature. 2015.
  6. K. Sirinukunwattana, S. E. A. Raza, Y. W. Tsang, D. R. J. Snead, I. A. Cree, and N. M. Rajpoot, ?Locality Sensitive Deep Learning for Detection and Classification of Nuclei in Routine Colon Cancer Histology Images,? IEEE Trans. Med. Imaging, 2016.
  7. C. Szegedy,W. Liu, Y. Jia, P. Sermanet, S. Reed, D. Anguelov, D. Erhan, V. Vanhoucke, A. Rabinovich et al., ?Going deeper with convolutions,? in Computer Vision and Pattern Recognition (CVPR), 2015 IEEE Conference on. Cvpr, 2015.
  8. A. Krizhevsky, I. Sutskever, and G. E. Hinton, ?Imagenet classification with deep convolutional neural networks,? in Advances in neural information processing systems, 2012, pp. 1097?1105.
  9. K. Simonyan and A. Zisserman, ?Very deep convolutional networks for large-scale image recognition,? International Conference on Learning Representations (ICLR) (oral), 2015.
  10. G. Huang, Z. Liu, K. Q.Weinberger, and L. van der Maaten, ?Densely connected convolutional networks,? in Proceedings of the IEEE conference on computer vision and pattern recognition, vol. 1, no. 2, 2017, p. 3.
  11. L. Shen, L. R. Margolies, J. H. Rothstein, E. Fluder, R. McBride, and W. Sieh, ?Deep Learning to Improve Breast Cancer Detection on Screening Mammography,? Sci. Rep., 2019.
  12. R. Yan et al., ”Breast Cancer histopathological image classification using a hybrid deep neural network,” Methods, 2019.
  13. B. Zhang, ?Breast cancer diagnosis from biopsy images by serial fusion of Random Subspace ensembles,? in Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011, 2011.
  14. K. Das, S. Conjeti, A. G. Roy, J. Chatterjee, and D. Sheet, ?Multiple instance learning of deep convolutional neural networks for breast histopathology whole slide classification,? in Proceedings - International Symposium on Biomedical Imaging, 2018.
  15. S. Akbar, M. Peikari, S. Salama, S. Nofech-Mozes, and A. L. Martel, ?The transition module: a method for preventing overfitting in convolutional neural networks,? Comput. Methods Biomech. Biomed. Eng. Imaging Vis., 2019.
  16. F. A. Spanhol, L. S. Oliveira, C. Petitjean, and L. Heutte, ’Breast cancer histopathological image classification using convolutional neural networks,’ in Proc. Int. Joint Conf. Neural Netw. (IJCNN), Jul. 2016, pp. 2560-2567.
  17. N. Bayramoglu, J. Kannala, and J. Heikkil, ”Deep learning for magnification independent breast cancer histopathology image classification,” in Proc. 23rd Int. Conf. Pattern Recognit. (ICPR), Dec. 2016, pp. 2440-2445.
  18. G. Litjens, T. Kooi, B.E. Bejnordi, S. Aaa, F. Ciompi, M. Ghafoorian, V.D.L. Jawm, G.B. Van, C.I. S nchez, A survey on deep learning in medical image analysis, Med. Image Anal. 42 (2017) 60?88.
  19. Pan S.J, Yang Q. ”A survey on transfer learning.” IEEE Transaction on Knowledge Data Engineering 2010;22(10):1345?59.
  20. D. Bardou, K. Zhang, and S. M. Ahmad, ?Classification of Breast Cancer Based on Histology Images Using Convolutional Neural Networks,? IEEE Access, 2018.
  21. Sebastian Ruder. ?An overview of gradient descent optimization algorithms?. In: CoRRabs/1609.04747 (2016).URL:http://arxiv.org/abs/1609.04747.
  22. J. Duchi, E. Hazan, and Y. Singer, ?Adaptive subgradient methods for online learning and stochastic optimization,? in COLT 2010 - The 23rd Conference on Learning Theory, 2010.
  23. D. P. Kingma and J. L. Ba, ?Adam: a Method for Stochastic Optimization,? Int. Conf. Learn. Represent. 2015, 2015.
  24. G. E. Hinton, N. Srivastava, and K. Swersky, ?Lecture 6aoverview of mini-batch gradient descent,? COURSERA Neural Networks Mach. Learn., 2012.
  25. L. Liu et al., ?On the Variance of the Adaptive Learning Rate and Beyond.? In: CoRRabs/1908.03265 (2019).URL:https://arxiv.org/abs/1908.03265
  26. A. Janowczyk and A. Madabhushi, ?Deep learning for digital pathology image analysis: A comprehensive tutorial with selected use cases,? J. Pathol. Inform., 2016.
  27. A. Cruz-Roa et al., ?Automatic detection of invasive ductal carcinoma in whole slide images with convolutional neural networks,? in Medical Imaging 2014: Digital Pathology, 2014.
  28. S. Ioffe and C. Szegedy, ?Batch normalization: Accelerating deep network training by reducing internal covariate shift,? in 32nd International Conference on Machine Learning, ICML 2015, 2015.
  29. F. Chollet, ?Keras: Deep Learning for humans,? Github, 2015. M. Abadi et al., ?TensorFlow: Large-Scale Machine Learning on Heterogeneous Distributed Systems,? 2016.
Index Terms

Computer Science
Information Sciences

Keywords

Breast Cancer Convolutional Neural Networks Deep Learning Classification Optimization methods