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Modelling and Simulation of Microparticles Separation using Standing Surface Acoustic Waves (SSAWs) Microfluidic Devices for Biomedical Applications
| International Journal of Computer Applications |
| Foundation of Computer Science (FCS), NY, USA |
| Volume 129 - Number 9 |
| Year of Publication: 2015 |
| Authors: Ahmed M. Soliman, Mohamed A. Eldosoky, Taha E. Taha |
10.5120/ijca2015906978
|
Ahmed M. Soliman, Mohamed A. Eldosoky, Taha E. Taha . Modelling and Simulation of Microparticles Separation using Standing Surface Acoustic Waves (SSAWs) Microfluidic Devices for Biomedical Applications. International Journal of Computer Applications. 129, 9 ( November 2015), 30-38. DOI=10.5120/ijca2015906978
Abstract
The design of significant and powerful standing surface acoustic wave (SSAW) microfluidic device for microparticles separation for biomedical applications is depending on the dimensions of microchannels for the collecting microparticles. For this purpose, precise calculations of the displacement of microparticles in the working area of SSAW microfluidic device are required. In this paper, the theory and principles of using SSAW microfluidic devices for particles separation are described. The almost published papers in this field had taken into account only the effect of SSAW and viscous drag forces, but the microparticles in the separation process can be affected by other forces. Therefore, the forces acting on the microparticles in fluid flow in SSAW microfluidic devices such as hydrodynamic and diffusion forces are analyzed by mathematical models. Also, the SSAW force is affected by Rayleigh angle, therefore, the SSAW force with the effect of Rayleigh angle which acting on the microparticles is analyzed by mathematical model. The simulation programs are also built by Matlab program to calculate the displacement of microparticles based on the effect of SSAW and viscous drag forces alone; and based on the effect of SSAW with Rayleigh angle effect, viscous drag, hydrodynamic, and diffusion forces. Two types of microparticles different in size and two types of microparticles different in density are separately simulated to verify these programs and show the effects of this analysis. The analysis and simulation of these effects are positively led to more accurate calculations of the displacement of microparticles in the SSAW microfluidic device.
References
- M. Hejazian, W. Li, and NT. Nguyen, 2015, "Lab on a Chip for Continuous-Flow Magnetic Cell Separation" Lab on Chip, vol. 15, pp. 959–970.
- M. G. Lee, J. H. Shin, C. Y. Bae, S. Choi, and JK. Park, 2013, "Label-Free Cancer Cell Separation from Human Whole Blood Using Inertial Microfluidics at Low Shear Stress" Anal. Chem., vol. 85, pp. 6213–6218.
- T. Baciu, F. Borrull, C. Aguilar, and M. Calull, 2015, "Recent Trends in Analytical Methods and Separation Techniques for Drugs of Abuse in Hair" Analytica Chimica Acta, vol. 856, pp. 1–26.
- George M. Whitesides, 2006, "The Origins and The Future of Microfluidics" Nature, vol. 442, pp. 368-373.
- Tabeling P., 2005, Introduction to Microfluidics, New York: Oxford Univ. Press.
- T. M. Geislinger, S. Chan, K. Moll, A. Wixforth, M. Wahlgren, and T. Franke, 2014, "Label-Free Microfluidic Enrichment of Ring-Stage Plasmodium Falciparum-Infected Red Blood Cells Using Non-Inertial Hydrodynamic Lift" Malaria Journal, vol. 13, pp. 1–8.
- A. Karimi, S. Yazdi, and A. M. Ardekani, 2013, "Hydrodynamic Mechanisms of Cell and Particle Trapping in Microfluidics" Biomicrofluidics, vol. 7, pp. 1–23.
- M. Mohammadi, H. Madadi, J. Casals-Terré, and J. Sellarès, 2015, "Hydrodynamic and Direct-Current Insulator-Based Dielectrophoresis (H-DC-Idep) Microfluidic Blood Plasma Separation" Anal. Bioanal. Chem., vol. 407, pp. 4733–4744.
- Y. Jia, Y. Ren, and H. Jiang, 2015, "Continuous Dielectrophoretic Particle Separation Using A Microfluidic Device with 3D Electrodes and Vaulted Obstacles" Electrophoresis, vol. 36, pp. 1744–1753.
- J. Xia, X. Chen, C.Z. Zhou, Y.G. Li, and Z.H. Peng, 2011, "Development of A Low-Cost Magnetic Microfluidic Chip for Circulating Tumour Cell Capture" IET Nanobiotechnology, vol. 5, pp. 114–120.
- S. H. S. Lee, T. A. Hatton, and S. A. Khan, 2011, "Microfluidic Continuous Magnetophoretic Protein Separation Using Nanoparticle Aggregates" Microfluidics and Nanofluidics, vol. 11, pp. 429–438.
- A. Lee, J. Park, M. Lim, V. Sunkara, S. Y. Kim, G. H. Kim, M. Kim, and Y. Cho, 2014, "All-in-One Centrifugal Microfluidic Device for Size-Selective Circulating Tumor Cell Isolation with High Purity" Anal. Chem., vol. 86, pp. 11349–11356.
- L. Clime, D. Brassard, M. Geissler, and T. Veres, 2015, "Active Pneumatic Control of Centrifugal Microfluidic Flows for Lab-on-a-Chip Applications" Lab Chip, vol. 15, pp. 2400–2411.
- T. E. Taha, M. A. A. El-Dosoky and A. M. El-Sayed, 2007, "On the Analysis of the Interaction between Surface Acoustic Wave (SAW) and Adjacent Media" The 24th National Radio Science Conference (NRSC), Cairo, Egypt.
- M. S. Zaghloul, T. E. Taha, A. H. A. Moustafa, and K. El-Shennawy, 2001, "Modeling and Simulation of Fluid SAW-Sensors under Acoustic Plate Mode Operation" IEEE Transactions on Instrumentation and Measurement, vol. 50, pp. 95-100.
- T. E. Taha, M. A. A. El-Dosoky and A. M. El-Sayed, 2009, "Estimation of Mixing Ratios of Two Mixture Solutions Using Shear Horizontal Surface Acoustic Wave (SH-SAW) Sensors" The 26th National Radio Science Conference (NRSC), Cairo, Egypt.
- T. E. Taha, M. A. A. El-Dosoky and A. M. El-Sayed, 2009, “The Effect of the Loss Tangent of the Blood and the Glucose on the Perturbation of the Shear Horizontal Surface Acoustic Wave” The 26th National Radio Science Conference (NRSC), Cairo, Egypt.
- L. Voiculescu, and A. N. Nordin, 2012, "Acoustic Wave based MEMS Devices for Biosensing Applications" Biosensors and Bioelectronics, vol. 33, pp. 1-9.
- M. C. Jo and R. Guldiken, 2012, "Active Density-Based Separation Using Standing Surface Acoustic Waves" Sensors and Actuators A, vol. 187, p.p. 22-27,.
- J. Nam, H. Lim, D. Kim, and S. Shin, 2011, "Separation of Platelets from Whole Blood Using Standing Surface Acoustic Waves in A Microchannel" Lab on Chip, vol. 11, pp. 3361–3364.
- F. Petersson, L. Aberg, AM. Sward-Nilsson, and T. Laurell, 2007, "Free Flow Acoustophoresis: Microfluidic-Based Mode of Particle and Cell Separation" Anal. Chem., vol. 79, p.p. 5117-5123.
- K. Yosioka, and Y. Kawasima, Y., 1955, "Acoustic Radiation Pressure on A Compressible Sphere" Acustica, vol. 5, pp. 167–173.
- T. Laurell, F. Petersson and A. Nilsson, 2007, "Chip Integrated Strategies for Acoustic Separation and Manipulation of Cells and Particles" Chem. Soc. Rev., vol. 36, pp. 492–506.
- F.M. White, 1999, Fluid Mechanics, McGraw-Hill.
- J. Shi, D. Ahmed, X. Mao, S. S. Lin, A. Lawit and T. J. Huang, 2009, "Acoustic Tweezers Patterning Cells and Microparticles Using Standing Surface Acoustic Waves (SSAW)" Lab Chip, vol. 9, pp. 2890–2895.
- G. B. Lee, C. C. Chang, S. B. Huang and R. J. Yang, 2006, "The Hydrodynamic Focusing Effect inside Rectangular Microchannels" Journal of Micromechanics and Microengineering, vol. 16, pp. 1024-1032.
- T. Stiles, R. Fallon, T. Vestad, J. Oakey, D. Marr, J. Squier and R. Jimenez, 2005, "Hydrodynamic Focusing for Vacuum-Pumped Microfluidics" Microfluidics and Nanofluidics, vol. 1, p.p. 280-283.
- H. Bruus, 2008, Theoretical Microfluidics, Oxford University Press.
- B. H. Weigl and P. Yager, 1999, "Microfluidic Diffusion-Based Separation and Detection" Science, vol. 283, p.p. 346-347.
- Y. Ai, C. K. Sanders, and B. L. Marrone, 2013, "Separation of Escherichia coli Bacteria from Peripheral Blood Mononuclear Cells Using Standing Surface Acoustic Waves", Anal. Chem., vol. 85, p.p. 9126-9134.
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