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Reseach Article

A Novel Genetic Programming Approach for Inferring Gene Regulatory Network

by M.n.vamsi Thalatam, Allam Appa Rao
International Journal of Computer Applications
Foundation of Computer Science (FCS), NY, USA
Volume 119 - Number 15
Year of Publication: 2015
Authors: M.n.vamsi Thalatam, Allam Appa Rao
10.5120/21147-4213

M.n.vamsi Thalatam, Allam Appa Rao . A Novel Genetic Programming Approach for Inferring Gene Regulatory Network. International Journal of Computer Applications. 119, 15 ( June 2015), 43-46. DOI=10.5120/21147-4213

@article{ 10.5120/21147-4213,
author = { M.n.vamsi Thalatam, Allam Appa Rao },
title = { A Novel Genetic Programming Approach for Inferring Gene Regulatory Network },
journal = { International Journal of Computer Applications },
issue_date = { June 2015 },
volume = { 119 },
number = { 15 },
month = { June },
year = { 2015 },
issn = { 0975-8887 },
pages = { 43-46 },
numpages = {9},
url = { https://ijcaonline.org/archives/volume119/number15/21147-4213/ },
doi = { 10.5120/21147-4213 },
publisher = {Foundation of Computer Science (FCS), NY, USA},
address = {New York, USA}
}
%0 Journal Article
%1 2024-02-06T23:05:00.347198+05:30
%A M.n.vamsi Thalatam
%A Allam Appa Rao
%T A Novel Genetic Programming Approach for Inferring Gene Regulatory Network
%J International Journal of Computer Applications
%@ 0975-8887
%V 119
%N 15
%P 43-46
%D 2015
%I Foundation of Computer Science (FCS), NY, USA
Abstract

Computational intelligence (CI) techniques are well suited to many of the problems arising in biology as they have flexible information processing capabilities for handling huge volume of real life data with noise, ambiguity, missing values, and so on. To process the executed knowledge through CI approaches needs techniques from computer science & engineering, mathematics and statistics. It involves in- depth study with in the areas of genomic signals, gene regulation and homeostatic regulation. The evolutionary computing techniques like genetic programming plays vital role to effectively resolve several crucial problems related to genomics. The core objective of this work is to study and model the different regulation mechanisms involved in the living organisms and propose accurate evolutionary algorithms for inferring Gene Regulatory Networks.

References
  1. T. M. N Vamsi, et. al "Inferring gene regulatory network through genetic programming and polish notation", Proc. of Int. Conf. on Advances in Communication, Network, and Computing, CNC, Elsevier, pp: 807-814. ISBN: 978-81-910691-7-8. (2014).
  2. Khalid raza, Rafat parveen, Evolutionary algorithms in Genetic regulatory networks model, ISSN 0976-2604 ,Vol 3, Issue 1, 2012, pp 271-280, Journal of Advanced Bioinformatics Applications and Research.
  3. Hidde De Jong, " Modelling and Simulation of Genetic Regulatory Systems: A Literature Review", Journal of Computational Biology, Volume 9, number 1,Pp. 67-103, 2002.
  4. Sanjoy Das,Doina C, S M Welch, William. H Hsu, "Handbook of Research on computational methodologies in Gene Regulatory Networks", Pp. 1-5,Medical Information Science
  5. Smolen, P. , Baxter, D. A. , and Byrne, J. H. 2000. Modeling transcriptional control in gene networks: Methods, recent results, and future directions. Bull. Math. Biol. 62, 247–292.
  6. Christopher, David Wild Review on " How to infer Gene Networks from expression profiles, revisited, Interface Focus(2011), 1,857-870,doi:10. 1098.
  7. F. He. R. Balling & A. Zeng, " Reverse engineering and verification of gene networks: Priniples, assumptions and limitations of present methods and future perspectives," vol. 144, pp. 190-203,2009.
  8. J. Yu, V. A. Smith, P. P. Wang, A. J. Hartemink, and E. D. Jarvis, "Advances to Bayesian network inference for generating causal networks from observational Biological data," Bioinformatics, vol. 20, pp. 3594–3603,(2004).
  9. Della Gatta et. al "Direct targets of the TRP63 TFs revealed by a combination of gene expression profiling and reverse engineering". GenomeRes. 18,939-948. (2008)
  10. Bansal et. al, Inference of gene regulatory networks and compound mode of action from time course gene expression profiles. Bioinformatics 22, 815-822,doi: 10. 1093(2006).
  11. Leonardo Vanneschi et. al, "Gene regulatory networks reconstruction from time series datasets using genetic programming: a comparison between tree-based and graph-based approaches", Genetic Programming and Evolvable Machines, Volume 14, Issue 4, pp 431-455,(2013). .
  12. Cantone,I. et. al. A Yeast synthetic network for in vivo assessment of reverse-engineering and modeling approaches. Cell 137,172-181,Elsevier Inc,April 2009.
  13. D'haeseleer, P. , et al. "Linear Modeling of mRNA Expression Levels During CNS Development and Injury" Pacific Symposium on Biocomputing 4: 41-52, (1999).
  14. Bansal et. al," How to infer gene networks from expression profiles", Mol. Syst. biology. 3,78 (2007).
Index Terms

Computer Science
Information Sciences

Keywords

Computational intelligence genetic programming Gene Regulatory Networks.